7. Impaired Adrenal Gland Function
Your adrenal glands produce cortisol. Your cells recognize the synthetic version of this hormone during steroid therapy. This means that your adrenals produce fewer hormones.
Symptoms of adrenal fatigue include severe fatigue, loss of appetite, weight loss, nausea, vomiting, diarrhea, muscle weakness, irritability, and depression (14).
Just a few weeks of prednisone at a dose of 10 mg will diminish your body’s ability to fight in a stressful situation.
8. Thin Skin
Corticosteroids influence all phases of wound healing, including bruising.
A study published in the American Journal of Surgery found that “patients treated for 30 days prior to wounding or an operative procedure were reported to have had a 2-fold increase in wound infection, 2 to 3 times higher incidence of wound dehiscence, and a 4 times greater mortality compared to those not taking steroids for that period of time” (15).
Taking corticosteroids can trigger severe acne. Varieties include acne vulgaris as well as Malassezia folliculitis, characterized by itchy bumps. Triggered by prednisone, both varieties of acne can get so bad that they cause lifelong acne scars (16).
10. Weight Gain
According to the University of California San Francisco “Weight gain while taking prednisone is typically due to fluid retention and increased calorie intake because of increased appetite.” Plus, patients are more likely to exercise less during their illness (17).
Weight gained while taking the drug normally settles in your abdomen, face and the back of your neck. One of the hallmark signs of prednisone usage is “moon face”, or the appearance of an unusually round face.