2. Fructose Causes Resistance to a Hormone Called Leptin
Leptin is one of the main hormones that your body uses to determine the balance between energy intake from food and energy expenditure through homeostasis and additional exertion (like exercise).
Like in the case of insulin resistance, fructose consumption causes the body to create more triglycerides, which can result in resistance to the hormone leptin.
As a result, the body begins to hold onto food energy – or in other words, calories and fat – that it doesn’t actually need.
This confusion also takes place in the brain, where resistant leptin receptors don’t get the message that the body doesn’t need any more food. As a result, you may continue to feel hungry even though you have consumed enough calories to fuel your body.
3. Fructose Does Not Cause Satiety In the Same Way as Glucose
Speaking of feeling hungry, fructose causes additional issues there. When your brain is exposed to glucose, the areas responsible for controlling hunger, motivation, and feelings of reward are activated, leading to a feeling of satiety and fullness or, at the very least, not feeling the need to consume any more sugar. Fructose, on the other hand, does not trigger this response.